New York City has long been one of the top vacation destinations in the U.S., and it’s easy to see why. From the world-class performances of Broadway to countless museums, there is endless entertainment for all ages in the Big Apple. Enjoy the big-city vibes on roads filled with street performers and vendors, or do some shopping at the world-class boutiques. Unique destinations like Chinatown and sprawling Central Park make for an unforgettable vacation experience. Best of all, New York City attractions are connected by one of the best public transportation systems in the country. Whether you’re seeking a trendy loft, a historic townhouse, or a designer hotel, here are nine of the best neighborhoods to find the perfect New York City vacation rental to fit your travel style.

1. Midtown

The beating heart of Manhattan, Midtown, and its towering skyscrapers put the city’s biggest attractions at your fingertips. Rentals here are just steps away from Times Square, the theaters of Broadway, and Central Park. You can also check out St. Patrick’s Cathedral or enjoy some shopping at the department stores. Head over to Grand Central Terminal for easy access to other neighborhoods and attractions. After a day of sightseeing, grab some fresh pretzels or hot dogs from one of the street vendors before making your way back up to your vacation rental to see the city lights from your window.

2. Chelsea

Fun and trendy, Chelsea is New York City’s hub of modern art, featuring countless art galleries you can browse while hanging around the neighborhood. You might also take a walk to Madison Square Park or Union Square for a relaxing afternoon. Offering everything from moderate-priced accommodations to luxury apartments, this neighborhood puts you close to top Manhattan attractions without sacrificing its relaxed atmosphere.

3. The Lower East Side

This funky neighborhood is known for its vibrant streets and cultural diversity, offering up plenty of things to do for when you’re hanging around your vacation rental between sightseeing excursions. Shop along Broadway, or enjoy a taste of New York at the eclectic restaurants, delis, and doughnut shops. You can also catch a movie at Sunshine Cinema, or browse the artwork of The New Museum. Don’t miss the Hester Street Fair on the weekend to sample some local eats.

4. TriBeCa

This more residential neighborhood boasts plenty of trendy lofts and high-end apartments that attract Manhattan’s most famous residents. Upscale restaurants abound for a nice night out, but you still find the active city street life that has made New York City famous. Take a stroll with your family down the streets to sample street food and spot celebrities, or head over to Hudson River Park for a laid-back afternoon. You might even catch the events of the annual Tribeca Film Festival.

5. The Financial District

Enjoy a stay among the historic streets and antiquated buildings of New York City’s oldest neighborhood to enjoy easy access to many top museums. The Financial District is ideal for a quieter vacation, especially at night when the New York bustle dulls to a lull, ensuring a great night’s sleep at your vacation rental before another day of New York sightseeing. Located on the southern tip of Manhattan, this neighborhood is a little farther from the action, but the city views you can catch from the Staten Island Ferry are well worth the extra distance.

6. Upper West Side

Featuring a laid-back atmosphere and a jungle of high-rise apartment buildings, this family-friendly neighborhood offers a host of entertainment options just a short walk from your vacation rental. Walk along the Hudson River while sipping your morning coffee, or enjoy the trails and events of Central Park. You can also check out the American Museum of Natural History, Hayden Planetarium, and the Children’s Museum of Manhattan. This neighborhood is home to Lincoln Center, known for its top-notch theater performances and operas, but your family may be just as happy relaxing at Riverside Park after exploring the museums.

7. Upper East Side

Residential areas bordering Central Park make up this neighborhood, but you can also enjoy a rich collection of museums. Do some window shopping along Madison Avenue, or stroll Museum Mile to hit the Guggenheim Museum, the Metropolitan Museum of Art, and other world-class museums. Don’t miss the chance to see the neighborhood from the Roosevelt Island Aerial Tram during your stay.

8. Greenwich Village

Greenwich Village boasts charming townhomes interspersed with cozy lofts and historic hotels, creating a unique neighborhood with bohemian vibes. Take a stroll to Washington Square Park to watch street performers in front of the fountain, and enjoy views of Washington Square Arch from your rental’s balcony. Head to one of the jazz or comedy clubs in the evening, and in the morning, take a short Metro ride to the city’s top museums.

9. Flatiron District

From its historic streets to its stunning high-rise buildings, the Flatiron District offers a truly special vacation experience. Fewer tourists mean plenty of vacation rentals at great prices, and you can enjoy easy access to Madison Square Park and Union Square. This neighborhood is known as one of New York’s biggest dining hot spots, so be sure to sample the Italian restaurants, fine dining establishments, and upscale bakeries.